Breakpoint indicators do not show up

For a short time now I have had a problem or pain with the Bre开发者_运维问答akpoint indicators, they do not show, yes I have the margin activated ( small grey stripe down the left side of the margin ). I have uninstalled all extensions, addins etc still no breakpoint indicator I have also deleted the .suo file with no go also. This is a major pain more than anything else. Anyone who has had this problem please help me out.

I once had this problem with VS2008. My solutions wasn't pretty, I had to reinstall it.